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GNAI2
Loading...Anti-GNAI2 Products
- Recombinant Mouse Anti-Human GNAI2 Antibody (MOB-2424MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IHC-Fr, IHC-P, ICC, IF
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- Anti-GNAI2 Immunohistochemistry Kit (VS-0325-XY934)
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- Species Reactivity: Human
- Target: GNAI2
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]
Protein class
Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. In this context, interacts with GNB2 (PubMed:28219978). Interacts with GPSM1 (By similarity). Interacts with RGS12 and RGS14 (By similarity). Interacts with UNC5B (PubMed:12359238). Interacts (inactive GDP-bound form) with NUCB1 (via GBA motif); the interaction leads to activation of GNAI3 (By similarity). Interacts (inactive GDP-bound form) with CCDC88C/DAPLE (via GBA motif) (PubMed:26126266). Interacts (inactive GDP-bound form) with CCDC8A/GIV (via GBA motif) (PubMed:19211784).
Molecular function
Transducer
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