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GRASP
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Adipocytes, dendritic cells, Macrophages, B-cells, Plasma cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HUVEC TERT2, TIME, WM-115)
Interaction
Heteromer. Composed of TAMALIN, CYTH2 and at least one GRM1. Also interacts with CYTH3, GRM2, GRM3 and GRM5 (By similarity).
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