GRIA1 Phosphorylation

GRIA1, also known as GluA1, is a crucial subunit of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptors, which are the predominant mediators of fast excitatory synaptic transmission in the mammalian central nervous system. These ligand-gated ion channels are essential for synaptic plasticity, a fundamental process underlying learning and memory. The precise regulation of GluA1 activity and localization, particularly through tyrosine and serine phosphorylation, is vital for modulating synaptic strength and neuronal function.