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GRK3
The beta-adrenergic receptor kinase specifically phosphorylates the agonist-occupied form of the beta-adrenergic and related G protein-coupled receptors. Overall, the beta adrenergic receptor kinase 2 has 85% amino acid similarity with beta adrenergic receptor kinase 1, with the protein kinase catalytic domain having 95% similarity. These data suggest the existence of a family of receptor kinases which may serve broadly to regulate receptor function.
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Alveolar cells type 2, Hofbauer cells, Extravillous trophoblasts, monocytes, Macrophages, granulocytes, Club cells)
Immune cell specificity
Group enriched (intermediate monocyte, non-classical monocyte, eosinophil, naive B-cell, memory B-cell, classical monocyte, myeloid DC, plasmacytoid DC)
Cell line specificity
Cell line enhanced (HDLM-2, JURKAT)
Interaction
Interacts with GIT1.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: ICC, IF, IHC-P, WB
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For Research Use Only. Not For Clinical Use.