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GRM5
Anti-GRM5 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, ICC, IF, IHC
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- Rabbit Anti-GRM5 Recombinant Antibody (clone CBACN-369) (MRO-0990-CN)
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, IF, IHC, IP, FC
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- Species Reactivity: Human, Mouse, Rat
- Type: Rabbit IgG
- Application: WB, ICC, IF, IHC, IP, FC
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- Camelid Anti-GRM5 Recombinant Single Domain Antibody (NBD-0064-YJ-VHH) (NBD-0064-YJ-VHH)
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- Species Reactivity: Human
- Type: Camelid VHH
- Application: ELISA
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- Chicken Anti-GRM5 Polyclonal IgY (BRD-0704MZ)
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- Species Reactivity: Human, Rat, Mouse
- Type: Chicken antibody
- Application: ICC/IF, IHC
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- Derivation: Phage display library
- Species Reactivity: Human
- Type: Rabbit IgG
- Application: WB, IHC-P, ICC, FC
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- Mouse Anti-GRM5 Recombinant Antibody (clone 1A11D10) (VS7-HM1040)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: IHC, ICC
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- Mouse Anti-GRM5 Recombinant Antibody (clone 8H5D5) (VS7-HM1041)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
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For Research Use Only. Not For Clinical Use.
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity.
Protein class
FDA approved drug targets, G-protein coupled receptors, Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Oligodendrocyte precursor cells, Inhibitory neurons, Excitatory neurons)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Not detected
Interaction
The PPXXF motif binds HOMER1, HOMER2 and HOMER3. Interacts with SIAH1, RYR1, RYR2, ITPR1, SHANK1, SHANK3 and TAMALIN. Interacts with NCDN (By similarity). Isoform 2 interacts with NECAB2 (PubMed:19694902). Interacts with CAMK2A (PubMed:28130356).
Molecular function
G-protein coupled receptor, Receptor, Transducer
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