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H2BFM

Anti-H2BFM Products
- Anti-Human H2BFM Recombinant Antibody (TAB-335CL)
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- Derivation: Humanized
- Species Reactivity: Human
- Type: Antibody
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- Derivation: Humanized
- Species Reactivity: Human
- Type: ADCC enhanced antibody
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- Species Reactivity: Human
- Type: Humanized IgG
- Application: ELISA, WB
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- Species Reactivity: Human
- Type: Humanized scFv
- Application: ELISA, WB
- Human Anti-H2BFM Recombinant Antibody; Fab Fragment (TAB-088CT-F(E)) (TAB-088CT-F(E))
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- Species Reactivity: Human
- Type: Humanized Fab
- Application: ELISA, WB
- Human Anti-H2BFM Antibody, mRNA (TAB-335CL-mRNA)
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- Species Reactivity: Human
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For Research Use Only. Not For Clinical Use.
Background
The antibodies bind to a human histone protein, such as H2B, H3 or H4 are of use to treat a variety of diseases that may be associated with histones, such as autoimmune disease, atherosclerosis, arthritis, rheumatoid arthritis, edema, sepsis, septic shock, hyperinflammatory disorder, infectious disease, inflammatory disease, immune dysregulatory disorder, GVHD, transplant rejection, atherosclerosis, asthma, a coagulopathy, myocardial ischemia, thrombosis, nephritis, inflammatory liver injury, acute pancreatitis, ischemia-reperfusion injury, stroke, cardiovascular disease, and burn.
Predicted location
Intracellular
Single cell type specificity
Not detected
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (hTERT-RPE1, Karpas-707)
Interaction
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Molecular function
DNA-binding
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