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H3F3C
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For Research Use Only. Not For Clinical Use.
Background
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene contains introns and its mRNA is polyadenylated, unlike most histone genes. The protein encoded by this gene is a replication-independent histone that is a member of the histone H3 family.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Cardiomyocytes, Smooth muscle cells, Fibroblasts, Endothelial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Cell line enhanced (SH-SY5Y)
Interaction
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.
Molecular function
DNA-binding
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