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HCN2

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For Research Use Only. Not For Clinical Use.


Background

Protein class

Transporters, Voltage-gated ion channels

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Oligodendrocytes, Bipolar cells, Horizontal cells, Inhibitory neurons, Rod photoreceptor cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (A549, HeLa, MCF7, U-138 MG, U-87 MG)

Interaction

The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Heterotetramer with HCN1. Forms an obligate 4:4 complex with accessory subunit PEX5L. Interacts with KCNE2 (By similarity). Homotetramer.

Molecular function

Ion channel, Ligand-gated ion channel, Potassium channel, Sodium channel, Voltage-gated channel

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