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HERC2
Anti-HERC2 Recombinant Antibody Products
- Recombinant Anti-Human HERC2 Antibody Fab Fragment (MOB-4067z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: IP, Neut, FuncS
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- Recombinant Anti-Human HERC2 Antibody scFv Fragment (MOB-4067z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: IP, IF, Biosensors, FuncS
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For Research Use Only. Not For Clinical Use.
This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16.
Protein class
Disease related genes, Enzymes, Human disease related genes, Metabolic proteins, Potential drug targets
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Low cell type specificity
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HEL)
Interaction
Interacts (when phosphorylated at Thr-4827 and sumoylated) with RNF8 (via FHA domain); this interaction increases after ionizing radiation (IR) treatment. Interacts with XPA. Interacts with NEURL4. Via its interaction with NEURL4, may indirectly interact with CCP110 and CEP97.
Molecular function
Transferase
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