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Anti-HIBADH Recombinant Antibody Products

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Anti-HIBADH ProductsHIBADHFeatured ProductsCustomer ReviewsrAb ProductionrAb Modalities

Anti-HIBADH Products

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For Research Use Only. Not For Clinical Use.


Creative Biolabs specializes in developing high-performance recombinant antibodies against HIBADH, engineered to accelerate breakthroughs in life science research through next-generation protein engineering methodologies. Our proprietary antibody development platform combines advanced structural optimization with multi-tiered quality validation protocols, yielding research-grade reagents with unparalleled binding affinity and batch-to-batch consistency. Researchers benefit from our extensive library of precision-formulated antibodies, each meticulously optimized to address complex experimental requirements across various disease models and therapeutic applications. Beyond supplying these superior biological tools, we offer comprehensive scientific partnership - including experimental design consultation, protocol optimization, and technical troubleshooting - to ensure successful implementation of our antibodies in your specific research context. This powerful synergy between premium-quality reagents and dedicated expert support creates an ideal framework for advancing your most ambitious research goals and translating innovative hypotheses into meaningful scientific discoveries with real-world impact.

HIBADH: A Key Mitochondrial Enzyme in Metabolic Disorders Neurodegeneration and Cancer

HIBADH has emerged as a critical metabolic regulator with broad implications in human disease pathology. As a key enzyme in valine catabolism, its dysfunction disrupts critical energy production pathways, leading to severe metabolic imbalances particularly affecting hepatic and muscular systems. Elevated activity has been observed in various malignancies, where it contributes to tumor microenvironment remodeling through altered mitochondrial metabolism and redox balance maintenance. The protein's involvement in reactive oxygen species regulation connects its aberrant function to neurodegenerative conditions and age-related degenerative processes. Genetic mutations affecting this dehydrogenase result in rare inborn errors characterized by developmental delays and metabolic acidosis, while acquired deficiencies correlate with progressive myopathies and cardiac dysfunction. In hepatic disorders, abnormal expression patterns correlate with disease progression and therapeutic resistance, potentially serving as both prognostic indicators and intervention points. The enzyme's unique structural features, including its NAD+ binding domain and tetrameric organization, present multiple opportunities for pharmacological modulation. Current research explores its therapeutic potential through selective inhibitors and gene-based approaches, though challenges persist in achieving organ-specific targeting. The growing recognition of its pleiotropic roles continues to uncover novel associations with metabolic syndrome components, cancer cachexia, and other systemic conditions, highlighting its importance as a multifunctional metabolic node in human pathophysiology.

Alternative Names

Complement HIBADH; NS5ATP1

Background

This gene encodes a mitochondrial 3-hydroxyisobutyrate dehydrogenase enzyme. The encoded protein plays a critical role in the catabolism of L-valine by catalyzing the oxidation of 3-hydroxyisobutyrate to methylmalonate semialdehyde.

Protein class

Enzymes, Metabolic proteins, Plasma proteins

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Distal tubular cells, Proximal tubular cells, Syncytiotrophoblasts)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Low cell line specificity

Interaction

Homodimer.

Molecular function

Oxidoreductase

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Anti-HIBADH rAb Products

Our goal is to promote faster scientific progress and innovation by offering recombinant antibodies against HIBADH that combine outstanding quality, excellent value, and comprehensive technical support to meet diverse research needs effectively.

Table 1. Featured anti-HIBADH recombinant antibody products at Creative Biolabs.

Cat. No. Product Name Target Species Host Species Applications
MOR-1594 Rabbit Anti-HIBADH Recombinant Antibody (clone DS1594AB) Human; Mouse; Rat Rabbit WB; IHC-P; ICC; IF; FC; IP

Customer Reviews

Excellent
D**id
Rabbit Anti-HIBADH Recombinant Antibody (clone DS1594AB) (CAT#: MOR-1594)
In Western blot analyses of human hepatic and skeletal muscle specimens, the Rabbit Anti-HIBADH Recombinant Antibody exhibited excellent target specificity, producing well-defined bands with negligible non-specific signal. The reagent demonstrated remarkable batch-to-batch consistency and straightforward handling characteristics, reliably detecting HIBADH expression across different biological matrices. These performance attributes confirm its suitability for robust protein detection applications in complex tissue samples.
12/Apr/2024
Excellent
Em**y
Rabbit Anti-HIBADH Recombinant Antibody (clone DS1594AB) (CAT#: MOR-1594)
In flow cytometry experiments involving human kidney cells, we evaluated the Rabbit Anti-HIBADH Recombinant Antibody and found it to provide precise and consistent labeling with low non-specific signal. The antibody was easy to handle and demonstrated stable performance across numerous independent assays, reinforcing its value as a reliable tool for the accurate detection of HIBADH in flow cytometric applications.
26/Sep/2023

rAb Production

Leveraging decades of specialized knowledge in engineered antibody development and optimization, we consistently produce rigorously validated research-grade antibodies with exceptional turnaround times. Our client-focused approach combines reliable product performance with responsive technical support, delivering precisely characterized antibody solutions that accelerate your research timelines while maintaining uncompromising quality standards.

Featured Anti-HIBADH Recombinant Antibody Production PlatformsFig.1 Anti-HIBADH recombinant antibody production: milligram-scale. (Creative Biolabs Original)
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Anti-HIBADH recombinant antibody production: gram-scale. (Creative Biolabs Original)Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to offering researchers an extensive variety of cutting-edge, high-quality recombinant antibodies available in multiple formats. We possess expertise in a wide range of antibody engineering methods and enhance our product offerings with tailored custom engineering services designed specifically to fulfill your unique scientific research needs.

Fig.3 Diverse anti-HIBADH recombinant antibody production and modalities. (Creative Biolabs Original)Fig.3 Full Length Anti-HIBADH Recombinant Antibody Production and Modalities.

Should you require additional insights into the HIBADH target, please feel free to reach out to our team via phone or email without delay. Our knowledgeable staff is readily available to address any inquiries or challenges you might face throughout your research, delivering the specialized support needed to ensure the successful execution of your experimental work.

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