Intracellular, Membrane (different isoforms)
Group enriched (Langerhans cells, Proximal enterocytes, Hofbauer cells, Macrophages, B-cells, Kupffer cells, monocytes, dendritic cells)
Low immune cell specificity
Cell line enhanced (CAPAN-2, Daudi, EFO-21, U-266/70, U-698)
Heterodimer of an alpha chain (DMA) and a beta chain (DMB) (PubMed:16547258, PubMed:9768757). Interacts with MHCII; this interaction mediates rapid selection of high-affinity peptides in a pH-dependent manner, with an optimum at pH 5.5 (PubMed:23260142).
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For Research Use Only. Not For Clinical Use.