HLF
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the proline and acidic-rich (PAR) protein family, a subset of the bZIP transcription factors. The encoded protein forms homodimers or heterodimers with other PAR family members and binds sequence-specific promoter elements to activate transcription. Chromosomal translocations fusing portions of this gene with the E2A gene cause a subset of childhood B-lineage acute lymphoid leukemias. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Protein class
Cancer-related genes, Disease related genes, Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Hepatocytes, Bipolar cells, Horizontal cells, Excitatory neurons, Microglial cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enriched (Hep G2)
Interaction
Binds DNA specifically as homodimer or heterodimer with other PAR factors.
Molecular function
DNA-binding
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