Anti-HMGCR Recombinant Antibody Products

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Anti-HMGCR Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is dedicated to offering premium recombinant antibodies engineered to target HMGCR, actively supporting and driving advancements in biomedical research. By harnessing state-of-the-art technological platforms, we ensure our products adhere to the strictest quality and performance benchmarks, providing researchers with reliable tools to advance their work. Our extensive portfolio of recombinant antibodies underscores our commitment to delivering dependable and high-value solutions tailored to diverse research needs. Beyond our top-tier antibodies, we provide comprehensive, tailored technical support designed to assist researchers at every phase of their projects, fostering a collaborative environment for success. Partnering with Creative Biolabs means gaining access to innovative research tools and a dedicated collaborator committed to being an integral part of your scientific journey, driving forward breakthroughs with excellence in both products and service.

HMGCR: A Central Enzyme in Cholesterol Metabolism and Cardiovascular Disease

HMGCR serves as a pivotal regulator in human pathophysiology through its rate-limiting role in cholesterol biosynthesis. This membrane-bound enzyme's dysregulation underlies various metabolic disorders, particularly hypercholesterolemia and atherosclerosis, where excessive activity contributes to plaque formation and cardiovascular complications. As the primary target of statin drugs, its inhibition represents a cornerstone in cardiovascular disease prevention, though genetic variations can influence therapeutic responses. Beyond lipid metabolism, aberrant expression patterns correlate with several malignancies, including breast and prostate cancers, where upregulated activity supports tumor growth through both cholesterol-dependent and independent mechanisms. The enzyme's complex regulation, involving sterol-sensing domains and post-translational modifications, creates multiple pathological vulnerabilities - mutations affecting these regulatory elements lead to rare inherited lipid disorders. Recent research reveals connections to neurological conditions, with altered activity observed in Alzheimer's disease and other neurodegenerative processes, potentially through impacts on membrane integrity and synaptic function. The protein's essential role in isoprenoid production further links its dysfunction to developmental abnormalities and immune system disorders. Current investigations continue to explore its therapeutic potential beyond cardiovascular applications, including oncology and neuroprotection, while addressing challenges in tissue-specific targeting and overcoming compensatory metabolic pathways.

Alternative Names

Complement HMGCR; HMG CoA Reductase; EC 1.1.1; 3-Hydroxy-3-Methylglutaryl-CoA Reductase; Hydroxymethylglutaryl-CoA Reductase; HMG-CoA Reductase; 3-Hydroxy-3-Methylglutaryl CoA Reductase (NADPH)

Background

HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-HMGCR rAb Products

Our unwavering commitment is to accelerate research and discovery by providing anti-HMGCR recombinant antibody products that embody the highest quality, exceptional value, and unparalleled technical support, all designed to empower researchers at every stage of their scientific journey.

Table 1. Featured anti-HMGCR recombinant antibody products at Creative Biolabs.

Creative Quality Control

To facilitate the progression of biopharmaceutical research through to successful commercialization, we emphasize a client-centered strategy focused on delivering superior-quality products. Our strict quality management system guarantees consistent excellence across all offerings. By surpassing client expectations, we aim to accelerate their drug development timelines and overall success.

Customer Reviews

Excellent

Mi**l
Mouse Anti-HMGCR Recombinant Antibody (clone 25B3) (CAT#: MOB-4038z)

We used the Mouse Anti-HMGCR Recombinant Antibody in ELISA assays with human liver tissue samples. The antibody showed good specificity and sensitivity, producing consistent and reliable results. It performed well under standard assay conditions without requiring extensive optimization. Overall, it is a dependable antibody for detecting HMGCR in ELISA applications.

21/Feb/2024

Excellent

Ma**w
Recombinant Rabbit Anti-HMGCR Antibody (clone R04-2J3) (CAT#: VS3-FY686)

In our Western blot experiments using human liver cell lysates, the Recombinant Rabbit Anti-HMGCR Antibody provided clear and specific bands with minimal background. It consistently detected HMGCR across multiple runs and integrated smoothly into our standard protocols without requiring additional optimization. This antibody is a reliable choice for HMGCR detection in WB applications.

25/Apr/2023

Excellent

D**el
Mouse Anti-HMGCR Recombinant Antibody (clone YC105) (CAT#: MOB-183CQ)

We tested the Mouse Anti-HMGCR Recombinant Antibody using immunofluorescence on human liver cells. The antibody gave clear and specific staining with minimal background. It worked well with our standard protocol and delivered consistent results. Overall, a reliable antibody for IF applications.

05/Oct/2023

rAb Production

Drawing on our extensive expertise in recombinant antibody development, we reliably deliver superior-quality products paired with outstanding customer service, guaranteeing prompt turnaround times to effectively support and enhance your research endeavors.

Featured Anti-HMGCR Recombinant Antibody Production Platforms
Fig.2 Milligram-scale recombinant antibody production.

Fig.3 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs dedicates itself to offering scientists an extensive variety of state-of-the-art recombinant antibodies in multiple formats. Our broad expertise covers numerous antibody engineering methods, and we deliver tailored custom engineering solutions crafted specifically to address your distinct research objectives and challenges.

Fig.4 Full Length Anti-HMGCR Recombinant Antibody Production and Modalities.

Should you seek further details regarding the HMGCR target, please feel free to reach out to our team via phone or email without hesitation. Our seasoned professionals stand ready to address any inquiries or challenges you might encounter throughout your experimental work, delivering the specialized support essential to ensure the successful outcome of your research endeavors.