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HOXB9
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For Research Use Only. Not For Clinical Use.
This gene is a member of the Abd-B homeobox family and encodes a protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded nuclear protein functions as a sequence-specific transcription factor that is involved in cell proliferation and differentiation. Increased expression of this gene is associated with some cases of leukemia, prostate cancer and lung cancer.
Protein class
Transcription factors
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Enteroendocrine cells, Collecting duct cells, Undifferentiated cells, Intestinal goblet cells, Distal tubular cells, Distal enterocytes)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (HDLM-2, HEK93, HMC-1, K-562)
Molecular function
Developmental protein, DNA-binding
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