Anti-HPD Recombinant Antibody Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs offers globally leading, innovative recombinant antibodies targeting HPD, serving as vital tools to drive biomedical research forward. Leveraging our advanced technological platforms, we ensure our products adhere to the strictest quality and performance standards. Our mission to accelerate research and discovery is embodied in our diverse portfolio of recombinant solutions, each engineered to deliver exceptional value and consistency. Beyond our premium antibodies, we take pride in providing unparalleled technical support to assist researchers at every phase of their projects. With Creative Biolabs, you gain access to cutting-edge solutions and a dedicated partner committed to your scientific success.

HPD: A Key Metabolic Regulator in Tyrosinemia and Neurological Disorders

HPD plays a critical role in tyrosine metabolism, with its dysfunction linked to hereditary tyrosinemia type III and potential implications in neurological disorders. As a key enzyme in phenylalanine/tyrosine catabolism, defective activity leads to abnormal accumulation of metabolic intermediates, particularly 4-hydroxyphenylpyruvate, which may contribute to neurocognitive impairments. In tyrosinemia type III, genetic mutations result in enzyme deficiency, causing elevated tyrosine levels associated with intellectual disability and occasional seizures. Emerging research suggests broader connections to metabolic dysregulation, including possible involvement in hepatic disorders due to disrupted tyrosine breakdown pathways. The enzyme's metabolic influence extends beyond its primary substrate, with secondary effects on dopamine and norepinephrine synthesis that may impact neurotransmitter balance. Recent studies also explore potential associations with certain cancers, where altered tyrosine metabolism could influence tumor microenvironment dynamics. Therapeutic strategies targeting this pathway include dietary management for metabolic disorders and investigational approaches using enzyme inhibitors or stabilizers. Understanding its multifaceted role in disease pathogenesis continues to reveal new diagnostic and treatment opportunities across multiple clinical specialties.

Alternative Names

Complement PPD; 4HPPD; GLOD3; 4-HPPD; HPPDASE

Background

The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene.

Anti-HPD rAb Products

We accelerate scientific progress by providing premium anti-HPD recombinant antibodies, combining exceptional performance with cost-effectiveness and expert technical assistance.

Table 1. Featured anti-HPD recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

Ze**r
Recombinant Mouse Anti-Human HPD Antibody (CAT#: MOB-1131MZ)

This recombinant mouse anti-human HPD antibody works reliably in ELISA applications with human liver tissue lysates and HepG2 cell extracts. We've observed good specificity at 1:1000 dilution with clean background in western blots. The antibody consistently detects the expected ~40kDa band. While we haven't tested it extensively in IHC, it shows promise for detecting endogenous protein in FFPE samples. Reasonable choice for basic research applications.

13/Oct/2024

Excellent

P**ix
Rabbit Anti-HPD Recombinant Antibody (clone DS1667AB) (CAT#: MOR-1667)

The Rabbit Anti-HPD performs well in WB with clear detection of the ~40kDa band in human liver samples and HEK293T overexpression lysates. At 1:2000 dilution, it shows good specificity with minimal non-specific binding. We've successfully used it for endogenous protein detection in mouse brain homogenates too.

22/Jul/2023

rAb Production

With decades of specialized experience in antibody engineering, we consistently produce premium recombinant antibodies while maintaining rapid turnaround times. Our optimized development process ensures researchers receive reliable, high-performance reagents without unnecessary delays.

Featured Anti-xx Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

At Creative Biolabs, we specialize in developing cutting-edge recombinant antibodies across multiple formats to meet diverse research needs. Leveraging advanced antibody engineering technologies, we provide customized solutions with tailored modification services to support your specific experimental requirements.

Fig.3 Full Length Anti-HPD Recombinant Antibody Production and Modalities.

For further details concerning HPD-related research applications, please don't hesitate to contact our technical support specialists through either phone or electronic correspondence. Our experienced scientific team stands ready to provide comprehensive guidance and practical solutions for any experimental difficulties you might encounter, offering tailored assistance to facilitate your investigative work with this particular molecular target.