Anti-HSD11B2 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is happy to provide a cutting-edge array of anti-HSD11B2 recombinant antibody solutions, developed to assist researchers and pharmaceutical developers worldwide. Our high-quality antibodies provide unparalleled specificity and consistency, accelerating your breakthroughs in endocrine research and therapeutic development. Discover the difference our expertise can make in your next project.

HSD11B2: A Pivotal target for Endocrine Disease Therapy

HSD11B2, or 11β-hydroxysteroid dehydrogenase type 2, is a crucial enzyme responsible for inactivating the potent glucocorticoid cortisol into its inactive metabolite, cortisone. This essential enzymatic conversion primarily occurs in mineralocorticoid target tissues like the kidney, colon, and salivary glands, thereby protecting mineralocorticoid receptors from illicit activation by cortisol, which would otherwise lead to apparent mineralocorticoid excess. Research extensively links HSD11B2 dysfunction to severe conditions such as Apparent Mineralocorticoid Excess (AME) syndrome and various forms of hypertension. Studying this critical target is paramount for unraveling the intricate complexities of steroid metabolism and developing novel, targeted therapeutic strategies for these and related endocrine disorders.

Alternative Names

11β-Hydroxysteroid dehydrogenase type 2; Corticosteroid 11-β-dehydrogenase isozyme 2; AME; AME1; HSD11K; HSD2; SDR9C3; hydroxysteroid (11-beta) dehydrogenase 2.

Background

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension. [provided by RefSeq, Feb 2010]

Anti-HSD11B2 rAb Products

Creative Biolabs’ anti-HSD11B2 recombinant antibody products are meticulously developed to offer superior performance. Utilizing advanced recombinant technology, these antibodies ensure exceptional batch-to-batch consistency, high specificity, and reduced background noise, which are critical for reliable and reproducible experimental results. This translates into more accurate data and accelerated research timelines for your projects.

Table 1. Featured anti-HSD11B2 recombinant antibody products at Creative Biolabs.

Creative Quality Control

Creative Biolabs implements rigorous quality control measures for all recombinant antibody products, including our anti-HSD11B2 line. Each antibody undergoes comprehensive validation through multiple applications such as ELISA, Western Blot, and IHC, ensuring optimal sensitivity and specificity. This meticulous process guarantees the highest standards of purity and functionality, providing you with confidence in your research outcomes.

Customer Reviews

rAb Production

The production of our anti-HSD11B2 recombinant antibodies leverages state-of-the-art expression systems and purification techniques. This advanced approach ensures the generation of highly pure, well-characterized antibodies free from host cell contaminants. Our streamlined production pipeline guarantees consistent quality and scalability, meeting the demands of both small-scale research and large-scale therapeutic development.

Featured Anti-HSD11B2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-HSD11B2 recombinant antibody production.

Fig.2 Gram-scale anti-HSD11B2 recombinant antibody production.

rAb Modalities

Our anti-HSD11B2 recombinant antibodies are offered in a diverse array of modalities, encompassing unconjugated, biotinylated, and various fluorescent conjugates. This comprehensive selection provides researchers with enhanced versatility, thereby accommodating a broad spectrum of experimental designs and analytical requirements.

Fig.3 Full-length anti-HSD11B2 recombinant antibody production and modalities.

Creative Biolabs is dedicated to supporting your scientific endeavors with premium-grade reagents. Our anti-HSD11B2 recombinant antibodies demonstrate our dedication to quality and innovation. If you are ready to advance your research or have specific requirements, please do not hesitate to contact us to discuss how we can best assist your project needs.