Anti-HSD17B10 Recombinant Antibody Products

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Anti-HSD17B10 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in developing high-precision recombinant antibodies against HSD17B10, engineered to drive transformative discoveries in biomedical research. Our integrated antibody production system merges next-generation molecular design with stringent validation protocols, delivering reagents with unmatched binding affinity and reproducibility. Researchers can access our extensive library of thoroughly characterized antibodies, each carefully optimized for superior functionality in various experimental systems. Beyond supplying these advanced research tools, our team provides customized scientific support - from study design consultation to data interpretation - ensuring optimal implementation of our antibodies in your specific research context. This unique integration of premium-quality biological reagents and expert scientific partnership creates an unparalleled framework for accelerating your most ambitious research goals.

HSD17B10: A Vital Enzyme in Neurodegeneration Metabolic Disorders and Hormone Related Cancers

HSD17B10 occupies a critical position in human pathology through its multifunctional roles in steroid metabolism and mitochondrial function. This moonlighting protein's aberrant activity contributes significantly to neurological disorders, particularly infantile neurodegenerative conditions characterized by impaired neurosteroid homeostasis and energy metabolism defects. Its involvement in amyloid-β peptide degradation establishes a direct connection to Alzheimer's disease pathogenesis, where reduced enzymatic activity correlates with disease progression. The protein's dual localization in both mitochondria and nuclei enables diverse pathological mechanisms, including disrupted steroid hormone conversion in endocrine-related cancers and impaired fatty acid oxidation in metabolic disorders. Mutations affecting this dehydrogenase cause severe X-linked mental retardation syndromes, while altered expression patterns have been observed in hepatocellular carcinoma and hormone-sensitive malignancies. Structural analyses reveal unique substrate-binding properties that could be exploited for therapeutic development, though challenges persist in achieving organ-specific modulation. The enzyme's participation in multiple metabolic pathways continues to uncover novel associations with age-related cognitive decline, metabolic syndrome components, and rare inborn errors of metabolism, highlighting its importance as a multifunctional node in disease networks. Current research explores its potential as both a diagnostic marker and therapeutic target across these diverse pathological conditions.

Alternative Names

Complement ABAD; CAMR; ERAB; HCD2; MHBD; HADH2; MRPP2; MRX17; MRX31; SCHAD; MRXS10; SDR5C1; 17b-HSD10; DUPXp11.22

Background

This gene encodes 3-hydroxyacyl-CoA dehydrogenase type II, a member of the short-chain dehydrogenase/reductase superfamily. The gene product is a mitochondrial protein that catalyzes the oxidation of a wide variety of fatty acids and steroids, and is a subunit of mitochondrial ribonuclease P, which is involved in tRNA maturation. The protein has been implicated in the development of Alzheimer disease, and mutations in the gene are the cause of 17beta-hydroxysteroid dehydrogenase type 10 (HSD10) deficiency. Several alternatively spliced transcript variants have been identified, but the full-length nature of only two transcript variants has been determined.

Anti-HSD17B10 rAb Products

Our unwavering commitment is to propel scientific research and innovation forward by offering anti - HSD17B10 recombinant antibodies that not only exhibit superior quality and exceptional value but also come paired with outstanding technical support tailored to meet researchers' diverse needs.

Table 1. Featured anti-HSD17B10 recombinant antibody products at Creative Biolabs.

Customer Reviews

Excellent

E**ly
Rabbit Anti-HSD17B10 Recombinant Antibody (clone DS1680AB) (CAT#: MOR-1680)

As a researcher, I found the Rabbit Anti-HSD17B10 Recombinant Antibody reliable for detecting HSD17B10 in human liver and brain tissues. It worked well in flow cytometry experiments, showing clear and specific staining with minimal background. The antibody was easy to use and compatible with our protocols. Overall, it provided consistent results and good sensitivity, making it a valuable tool for studying mitochondrial proteins in various cell types.

11/Jun/2024

Excellent

Ol**a
Rabbit Anti-HSD17B10 Recombinant Antibody (clone DS1680AB) (CAT#: MOR-1680)

I tested the Rabbit Anti-HSD17B10 Recombinant Antibody using human liver and kidney tissue samples. It performed well in western blot applications, providing clear and specific bands with low background noise. The antibody was straightforward to work with and showed good sensitivity and reproducibility. Overall, it met my expectations for studying HSD17B10 expression in these tissues.

22/Sep/2023

rAb Production

Boasting deep expertise in the development and optimization of recombinant antibodies, we are dedicated to providing exceptional service that ensures the timely and reliable delivery of high-quality recombinant antibody products, supported by our commitment to precision and efficiency at every stage.

Featured Anti-HSD17B10 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale recombinant antibody production.

Fig.2 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs is dedicated to equipping scientists with an extensive array of cutting-edge, premium recombinant antibodies available in various formats, reflecting our expertise in diverse recombinant antibody engineering techniques. Our portfolio is further strengthened by exceptional customized engineering solutions meticulously crafted to address the distinct and evolving research needs of our clients, ensuring tailored support at every stage of their scientific endeavors.

Fig.3 Full Length Anti-HSD17B10 Recombinant Antibody Production and Modalities.

For detailed insights about the HSD17B10 target, our expert scientific team welcomes your communication through either phone or email. We're prepared to offer immediate assistance with any technical questions or experimental obstacles, providing customized solutions to facilitate your research success - please reach out to us at your earliest convenience for personalized support.