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HSPB2

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For Research Use Only. Not For Clinical Use.


Background

The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The protein is expressed preferentially in the heart and skeletal muscle. This protein regulates Myotonic Dystrophy Protein Kinase, which plays an important role in maintenance of muscle structure and function. [provided by RefSeq, Dec 2012]
Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Cardiomyocytes, Leydig cells, Smooth muscle cells, Fibroblasts, Melanocytes)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1, fHDF/TERT166, HSkMC, LHCN-M2, U-138 MG)

Interaction

Interacts with DMPK; may enhance its kinase activity.

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