HSPBP1

Recombinant Antibody Products Formats

Anti-HSPBP1 Recombinant Antibody Products

Mouse Anti-HSPBP1 Recombinant Antibody (clone 4G8) (MOB-2675z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, FC, ICC, IF, IHC
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Chicken Anti-HSPBP1 Polyclonal IgY (BRD-0264MZ)
- Species Reactivity: Human, Mouse, Rat
- Type: Chicken antibody
- Application: WB
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For Research Use Only. Not For Clinical Use.

Inhibits HSPA1A chaperone activity by changing the conformation of the ATP-binding domain of HSPA1A and interfering with ATP binding. Interferes with ubiquitination mediated by STUB1 and inhibits chaperone-assisted degradation of immature CFTR.

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Respiratory ciliated cells)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HEK93)

Interaction

Interacts with the ATP-binding domain of HSPA1A. Detected in a ternary complex containing STUB1, HSPA1A and HSPBP1. Interacts with PGLYRP1; this interaction blocks the cytotoxic activity of the PGLYRP1-HSPA1A complex (PubMed:21247889).

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