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HTR2A

Anti-HTR2A Products

Mouse Anti-HTR2A Recombinant Antibody (clone 21D8) (MOB-4043z)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IP, IF, IHC, ELISA
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Mouse Anti-HTR2A Recombinant Antibody (clone CBH621) (MOB-327YJL)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ICC, IHC, IP
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PDZ domain scaffold protein anti-Human 5-HT2A Receptor (SPD-L153)
- Scaffold Name: PDZ domain
- Target: 5-HT2A Receptor
- Species Reactivity: Human
- Derivation: Phage display
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PDZ domain scaffold protein anti-Human 5-HT2C Receptor (SPD-L154)
- Scaffold Name: PDZ domain
- Target: 5-HT2C Receptor
- Species Reactivity: Human
- Derivation: Phage display
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For Research Use Only. Not For Clinical Use.

Background

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Protein class

FDA approved drug targets, G-protein coupled receptors, Human disease related genes

Predicted location

Membrane

Single cell type specificity

Cell type enriched (Excitatory neurons)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1, BEWO, HEL, U-138 MG, U-2 OS, U-87 MG)

Interaction

Interacts (via C-terminus) with MPDZ and PATJ (PubMed:11150294, PubMed:14988405). May interact (via C-terminus) with MPP3, PRDX6, DLG4, DLG1, CASK, APBA1 and MAGI2 (PubMed:14988405). Interacts with GRM2 and DRD2; this may affect signaling (PubMed:18297054, PubMed:21645528, PubMed:22300836).

Molecular function

G-protein coupled receptor, Host cell receptor for virus entry, Receptor, Transducer

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