Anti-HTR2A Recombinant Antibody Products

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Anti-HTR2A Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is dedicated to the development of high-efficiency recombinant anti-HTR2A antibodies, offering robust support for neuroscience and psychiatric research initiatives. By leveraging state-of-the-art protein engineering technologies, we deliver meticulously validated reagents that demonstrate exceptional specificity and batch-to-batch consistency, making them ideal for demanding applications such as single-cell analysis and super-resolution microscopy. Our comprehensive product portfolio not only emphasizes scientific accuracy but also ensures cost-effectiveness, catering to a wide spectrum of projects—from fundamental studies on serotonin receptor mechanisms to complex drug discovery workflows. In addition to these premium tools, we provide tailored experimental assistance, including protocol customization and issue resolution, to guarantee that your research on serotonin receptors not only meets but exceeds expectations in terms of accuracy and efficiency. This integrated approach combines technological innovation with personalized support, positioning us as a trusted partner for researchers seeking reliable solutions in their scientific endeavors.

HTR2A: A Multifunctional Therapeutic Target in Neuropsychiatric and Metabolic Disorders

HTR2A is implicated in a wide range of pathological conditions, particularly within the central nervous system. Its altered expression or signaling is strongly associated with various psychiatric and neurodevelopmental disorders, including schizophrenia, depression, bipolar disorder, and autism spectrum disorders. Dysregulation at this receptor site influences serotonin-mediated neurotransmission, affecting mood, cognition, perception, and emotional regulation. In schizophrenia, aberrant signaling contributes to symptoms such as hallucinations and cognitive deficits, and many antipsychotic medications act by modulating this pathway. In depressive disorders, disruptions in receptor balance are linked to impaired emotional processing and altered stress responses. Genetic polymorphisms affecting its function have also been connected to increased susceptibility to mood instability and suicidal behavior. Beyond mental health, the receptor has been implicated in conditions such as Alzheimer's disease, where serotonergic signaling deficits contribute to cognitive decline and behavioral disturbances. Additionally, its role in pain perception, sleep regulation, and gastrointestinal function broadens its relevance to somatic disorders. Because of its extensive involvement in diverse physiological processes and disease mechanisms, this target remains a critical focus in neuropharmacological research and therapeutic development.

Alternative Names

Complement HTR2A; HTR2; 5-HT2A; 5-Hydroxytryptamine (Serotonin) Receptor 2A, G Protein-Coupled; 5-HT-2; Serotonin 5-HT-2A Receptor; 5-HT2 Receptor; 5-Hydroxytryptamine Receptor 2A; 5-Hydroxytryptamine (Serotonin) Receptor 2A; 5-HT-2A; Serotonin Receptor 2A

Background

This gene encodes one of the receptors for serotonin, a neurotransmitter with many roles. Mutations in this gene are associated with susceptibility to schizophrenia and obsessive-compulsive disorder, and are also associated with response to the antidepressant citalopram in patients with major depressive disorder (MDD). MDD patients who also have a mutation in intron 2 of this gene show a significantly reduced response to citalopram as this antidepressant downregulates expression of this gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Anti-HTR2A rAb Products

These antibodies directed against HTR2A are well-suited for neuropsychiatric research, offering strong performance supported by thorough validation to ensure batch-to-batch consistency. Tailored for reliable use in techniques such as immunohistochemistry, western blotting, and immunoprecipitation, they provide an effective resource for both foundational studies on serotonin receptors and early-stage therapeutic exploration. Each product is supplied with comprehensive usage guidelines and access to expert technical support to assist with experimental design and troubleshooting.

Customer Reviews

Excellent

Ly**a
Mouse Anti-HTR2A Recombinant Antibody (clone 21D8) (CAT#: MOB-4043z)

This Mouse Anti-HTR2A antibody demonstrates reliable performance in ELISA applications, effectively detecting recombinant protein standards with linear quantification. It produced consistent results when testing transfected HEK293 cell lysates, though some background was observed with human prefrontal cortex samples, suggesting the need for optimized blocking conditions. While its performance in other applications remains untested, it serves as an economical choice for quantitative HTR2A analysis in lysate-based studies.

06/Feb/2024

Excellent

Z**ir
Mouse Anti-HTR2A Recombinant Antibody (clone CBH621) (CAT#: MOB-327YJL)

The Mouse Anti-HTR2A antibody performs effectively in Western blotting, producing a distinct ~50 kDa band when tested on lysates from transfected HEK293 cells. In brain tissue samples, faint non-specific bands were observed, which can be minimized by optimizing the blocking conditions. While this antibody is dependable for detecting overexpressed HTR2A, careful titration may be necessary to accurately identify endogenous protein levels in native tissues, ensuring reliable and specific results.

13/Jul/2023

rAb Production

Drawing on many years of specialized experience in antibody engineering, we develop premium recombinant antibodies through streamlined manufacturing processes that ensure exceptional quality and prompt delivery. Our enhanced production systems reliably generate rigorously validated reagents with unmatched efficiency and consistency, establishing a new standard within the field.

Featured Anti- HTR2A Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-HTR2A recombinant antibody production.

Fig.2 Gram-scale anti-HTR2A recombinant antibody production.

rAb Modalities

Creative Biolabs specializes in engineered antibody development across multiple formats, leveraging cutting-edge protein engineering technologies to meet diverse research requirements. Our platform integrates hybridoma, phage display, and recombinant antibody production methods, enabling customized solutions for applications ranging from basic research to clinical diagnostics and therapeutic development.

Fig.3 Full Length Anti-HTR2A Recombinant Antibody Production and Modalities.

If you have technical inquiries related to HTR2A, our experienced antibody specialists are available to provide personalized advice on experimental planning and optimization strategies. Reach out to us for customized assistance designed to meet the unique demands of your neuropharmacology research projects, ensuring you achieve the best possible results with our antibody products.