Anti-HTR2C Recombinant Antibody Products

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Anti-HTR2C Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specializes in premium recombinant antibodies targeting HTR2C, engineered to drive breakthroughs in neuropharmacology and metabolic research. Our advanced antibody development platforms deliver rigorously validated reagents with exceptional specificity and batch-to-batch consistency. Our extensive product portfolio delivers scientifically precise yet budget-friendly solutions, catering to a wide range of experimental needs—from target validation to drug discovery. Beyond supplying high-performance antibodies, we provide customized technical consultation throughout your project lifecycle. Partner with us to access expertly crafted tools and collaborative support for your serotonin receptor studies.

HTR2C: A Key Therapeutic Target in Metabolic and Neuropsychiatric Disorders

HTR2C, a serotonin receptor subtype, plays a crucial role in regulating appetite, mood, and metabolic processes. Dysfunction contributes to obesity and type 2 diabetes through impaired satiety signaling and glucose homeostasis, with selective agonists demonstrating appetite-suppressing effects in clinical trials. In psychiatric disorders, genetic variants associate with suicide risk and treatment-resistant depression, potentially influencing SSRI efficacy through downstream signaling pathways. The receptor's involvement in dopamine modulation links it to antipsychotic drug actions, though its activation can paradoxically exacerbate metabolic side effects. Premenstrual dysphoric disorder symptoms correlate with hormonal regulation of receptor expression patterns. Recent evidence suggests roles in addiction through reward pathway modulation, particularly in nicotine and cocaine dependence. Autoimmune conditions like Sjögren's syndrome show autoantibody interactions that may affect secretory functions. Therapeutic targeting remains complex due to opposing effects in different tissues, with ongoing development of biased ligands to separate metabolic benefits from psychiatric side effects. Polymorphisms influence individual drug responses, highlighting its pharmacogenomic importance in personalized medicine approaches for both neurological and metabolic conditions.

Alternative Names

Complement 5-Hydroxytryptamine Receptor 2C; 5-Hydroxytryptamine (Serotonin) Receptor 2C, G Protein-Coupled; 5-Hydroxytryptamine Receptor 1C; 5-HTR2C; 5-HT1C; 5-HT2C; HTR1C; 5-Hydroxytryptamine (Serotonin) Receptor 2C

Background

This gene encodes a seven-transmembrane G-protein-coupled receptor. The encoded protein responds to signaling through the neurotransmitter serotonin. The mRNA of this gene is subject to multiple RNA editing events, where adenosine residues encoded by the genome are converted to inosines. RNA editing is predicted to alter the structure of the second intracellular loop, thereby generating alternate protein forms with decreased ability to interact with G proteins. Abnormalities in RNA editing of this gene have been detected in victims of suicide that suffer from depression. In addition, naturally-occuring variation in the promoter and 5' non-coding and coding regions of this gene may show statistically-significant association with mental illness and behavioral disorders.

Anti-HTR2C rAb Products

We accelerate metabolic and neuropsychiatric research through rigorously validated anti-HTR2C antibodies that combine exceptional specificity with cost-efficient solutions and expert technical consultation.

Table 1. Featured anti-HTR2C recombinant antibody products at Creative Biolabs.

Creative Quality Control

We accelerate biopharmaceutical innovation from discovery to market by prioritizing customer needs through rigorous quality standards and efficient workflows. Our comprehensive quality systems ensure reliable products that exceed industry requirements, while our optimized processes help reduce development timelines without compromising performance.

Customer Reviews

Excellent

Ca**a
Rabbit Anti-HTR2C Recombinant Antibody (clone JA31-31) (CAT#: MRO-0011-CN)

The Rabbit Anti-HTR2C performs reliably in IHC on formalin-fixed human brain sections, showing clear neuronal staining in hypothalamic regions. We noticed some variability in cortical samples depending on fixation time. While it requires citrate-based antigen retrieval, background is minimal when optimized. It's a solid choice for CNS studies, though peripheral tissue applications may need further validation.

06/Oct/2024

Excellent

S**en
Rabbit Anti-HTR2C Recombinant Antibody (clone 9H8) (CAT#: ZG-0755J)

The Rabbit Anti-HTR2C works well in WB with HEK293 lysates, detecting a clean ~50kDa band. Some non-specific bands appeared in brain homogenates but were reduced with increased blocking. While suitable for overexpression systems, detection of endogenous protein in tissues may require optimization. A reliable option for basic expression analysis.

21/Nov/2023

rAb Production

With decades of specialized experience in antibody engineering, we develop premium recombinant antibodies through optimized production workflows that ensure both exceptional quality and rapid turnaround times. Our streamlined processes deliver rigorously validated reagents with industry-leading efficiency.

Featured Anti-HTR2C Recombinant Antibody Production Platforms
Fig.2 Milligram-scale recombinant antibody production.

Fig.3 Gram-scale recombinant antibody production.

rAb Modalities

Creative Biolabs specializes in engineered antibody solutions across multiple formats, leveraging cutting-edge design technologies to meet diverse research requirements. Our expertise spans advanced development platforms, enabling both standard and customized antibody services optimized for specific applications.

Fig.4 Full Length Anti-HTR2C Recombinant Antibody Production and Modalities.

For HTR2C-related technical inquiries or experimental optimization guidance, our antibody specialists provide comprehensive support tailored to your serotonin receptor research needs. Researchers may contact us through standard communication channels for detailed protocol recommendations and troubleshooting assistance throughout your project duration.