Helicobacter pylori babA
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For Research Use Only. Not For Clinical Use.
Background
Helicobacter pylori babA is a gene encoding the BabA (Blood group Antigen-Binding Adhesin) of Helicobacter pylori, a bacterium that colonizes the human gastric mucosa and causes gastritis, ulcers, etc. BabA mediates bacterial adhesion to host gastric epithelial cells by binding to Lewis b blood group antigens on the cell surface, a key step for colonization. It also enhances bacterial resistance to gastric acid, aiding survival in the harsh gastric environment. Studying babA helps understand Helicobacter pylori colonization mechanisms, and it is a potential target for drugs or vaccines to prevent gastric infections.