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IFT88
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the tetratrico peptide repeat (TPR) family. The encoded protein is involved in cilium biogenesis. Mutations of a similar gene in mouse can cause polycystic kidney disease. Several transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2017]
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Spermatocytes, Rod photoreceptor cells, Cone photoreceptor cells, Respiratory ciliated cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Component of the IFT complex B, at least composed of IFT20, IFT22, HSPB11/IFT25, IFT27, IFT46, IFT52, TRAF3IP1/IFT54, IFT57, IFT74, IFT80, IFT81, and IFT88 (By similarity). Interacts with IFT20, IFT22, HSPB11, IFT27, IFT52, TRAF3IP1, IFT74, IFT80 and IFT81 (By similarity). Interacts with IFT172 (By similarity). Interacts with IFT57 (By similarity). Interacts with IFT46 (By similarity). Interacts with TTC30B (By similarity). Interacts with C2CD3 (By similarity). Interacts with ENTR1 (via N-terminus) (PubMed:27767179). Interacts with LRRC56 (PubMed:30388400). Interacts with DZIP1 (By similarity).
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