IGF-IR
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Species Reactivity: Human
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Host Species: Human
Specificity: Human
Type: Human antibody
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): G0 (60.4%) G1 (35.5%) G2 (4.2%)
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Host Species: Human
Specificity: Human
Type: Human antibody
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): G0 (62.7%) G1 (33.0%) G2 (4.3%)
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Host Species: Human
Specificity: Human
Type: Human antibody
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): G0 (49.2%) G1 (43.6%) G2 (7.2%)
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Host Species: Human
Specificity: Human
Type: Human antibody
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): G0 (42.8%) G1 (48.7%) G2 (8.5%)
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Host Species: Human
Specificity: Human
Type: Human antibody
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): G0 (44.3%) G1 (47.6%) G2 (8.1%)
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Host Species: Human
Specificity: Human
Type: Human antibody
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): G0 (38.4%) G1 (51.4%) G2 (10.2%)
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Host Species: Human
Specificity: Human
Type: Human antibody
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): G0 (46.9%) G1 (45.9%) G2 (7.3%)
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Host Species: Human
Specificity: Human
Type: Human antibody
Glycosylation site: Asn297 in Fc region
Glycoform (ratio): G0 (40.4%) G1 (49.8%) G2 (9.8%)
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For Research Use Only. Not For Clinical Use.