Anti-IGF2R Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs is your trusted provider for cell signaling and lysosomal biology. We provide validated and highly specific anti-IGF2R recombinant antibodies. Insulin-Like Growth Factor 2 Receptor (IGF2R), also known as Cation-Independent Mannose-6-Phosphate Receptor (CI-M6PR), is a unique multi-functional receptor for both growth factor signaling and protein trafficking. Our high-quality antibodies are reliable tools for elucidating its dual roles in development, cancer, and lysosomal biogenesis.

IGF2R: The Dual-Function IGF2 and M6P Receptor

The IGF2R is a large, single-pass transmembrane protein that has two distinct and critical functions. First, it is a clearance receptor for the potent mitogen, insulin-like growth factor 2 (IGF2). Binding extracellular IGF2 and internalizing it for lysosomal degradation, IGF2R acts as a tumor suppressor by sequestering mitogenic IGF2 and preventing its signaling through IGF1R. Second, IGF2R is also the Cation-Independent Mannose-6-Phosphate Receptor (CI-M6PR) and is the major lysosomal enzyme trafficking receptor that shuttles newly synthesized mannose-6-phosphate-tagged enzymes from the Golgi to the lysosome.

Alternative Names

IGF2R; CI Man-6-P Receptor; M6PR; Insulin-Like Growth Factor II Receptor; IGF-II Receptor; CIMPR; CI-MPR; MPR 300; M6P-R; MPRI; CD222 Antigen; Cation-Independent Mannose-6-Phosphate Receptor; M6P/IGF2R

Background

IGF2R is a gene that encodes a receptor for the insulin-like growth factor 2 (IGF2), a protein involved in growth and development. The IGF2R receptor primarily functions by clearing IGF2 from the bloodstream, regulating its levels, and preventing overactivation of IGF2-mediated signaling. This is important for controlling cellular growth and differentiation, as dysregulation can lead to abnormal growth or contribute to cancer development. IGF2R is also involved in cellular processes such as endocytosis and is implicated in diseases like cancer, particularly in the regulation of tumor growth and metastasis.

Anti-IGF2R rAb Products

Our anti-IGF2R recombinant antibodies are optimized for exceptional specificity and performance. They are carefully validated to accurately detect this large receptor. Further optimized for use in IHC, Western Blot, and flow cytometry to measure cell surface expression, our rAbs are the tools you need for rigorous research into this receptor's dual functions.

Table 1. Featured anti-IGF2R recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

At Creative Biolabs, we provide cutting-edge antibody production platforms to support the highly specialized field of cell signaling research. Our anti-IGF2R recombinant antibodies are expressed in optimized systems to ensure that they precisely recognize the native receptor. We take this approach to guarantee that you get the highly specific and active research tools that your experiments deserve.

Featured Anti-IGF2R Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-IGF2R recombinant antibody production.

Fig.2 Gram-scale anti-IGF2R recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to enabling scientific discovery by providing flexible antibody solutions to meet your research needs. We provide our anti-IGF2R recombinant antibodies in a variety of modalities to support the diverse needs of researchers across the globe studying this important receptor.

Fig.3 Full-length anti-IGF2R recombinant antibody production and modalities.

Probe both functions of the IGF2R with the specificity of Creative Biolabs' anti-IGF2R recombinant antibodies. Our portfolio provides the validation and lot-to-lot consistency your research demands. Contact our scientific team today.