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IGFBP3
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- Anti-IGFBP3 Immunohistochemistry Kit (VS-0325-XY1108)
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- Species Reactivity: Human
- Target: IGFBP3
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein forms a ternary complex with insulin-like growth factor acid-labile subunit (IGFALS) and either insulin-like growth factor (IGF) I or II. In this form, it circulates in the plasma, prolonging the half-life of IGFs and altering their interaction with cell surface receptors. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Protein class
Cancer-related genes, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Extravillous trophoblasts, Urothelial cells, Basal respiratory cells, Fibroblasts, Basal keratinocytes)
Immune cell specificity
Immune cell enriched (plasmacytoid DC)
Cell line specificity
Cell line enhanced (fHDF/TERT166, U-2197, U-87 MG)
Interaction
Interacts with XLKD1 (By similarity). Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with humanin; humanin competes with importin KPNB1 for binding to IGFBP3, blocking IGFBP3 nuclear import and IGFBP3-mediated apoptosis (PubMed:14561895, PubMed:19623253, PubMed:26216267). Interacts with TMEM219.
Molecular function
Growth factor binding
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