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    IGFBP4

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    For Research Use Only. Not For Clinical Use.


    Background

    This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors.
    IGFBP4
    Protein class

    Plasma proteins

    Predicted location

    Secreted

    Single cell type specificity

    Cell type enhanced (Adipocytes, Fibroblasts, Hepatic stellate cells, Endometrial stromal cells, Endothelial cells, Hepatocytes)

    Immune cell specificity

    Group enriched (NK-cell, MAIT T-cell)

    Cell line specificity

    Cell line enhanced (A549, ASC diff, ASC TERT1, BJ, BJ hTERT+, HSkMC, U-2197)

    Interaction

    Binds IGF2 more than IGF1.

    Molecular function

    Growth factor binding

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