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IL17RE

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For Research Use Only. Not For Clinical Use.


This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]
Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Distal enterocytes, Proximal enterocytes, Gastric mucus-secreting cells, Intestinal goblet cells, Undifferentiated cells, Paneth cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (ASC diff, ASC TERT1, hTCEpi, T-47d)

Interaction

Forms heterodimers with IL17RA; the heterodimer binds IL17C.

Molecular function

Receptor

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