Intracellular
Low cell type specificity
Immune cell enhanced (basophil)
Low cell line specificity
Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (PubMed:16387653, PubMed:18794358). Interacts with H3K4me3 and to a lesser extent with H3K4me2 (PubMed:16728974, PubMed:18623064). Interacts with EP300 and p53/TP53 (PubMed:12750254). Interacts with INCA1 (PubMed:21750715).
Activator, Chromatin regulator
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For Research Use Only. Not For Clinical Use.