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ING5
Anti-ING5 Recombinant Antibody Products
- AbPlus™ Anti-ING5 Magnetic Beads (VS-0724-YC765) (VS-0724-YC765)
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- Target: ING5
- Target Species: Human
- Application: IP, Protein Purification
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- Anti-ING5 Immunohistochemistry Kit (VS-0325-XY1129)
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- Species Reactivity: Human
- Target: ING5
- Application: IHC
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For Research Use Only. Not For Clinical Use.
This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants. [provided by RefSeq, Aug 2016]
Predicted location
Intracellular
Single cell type specificity
Low cell type specificity
Immune cell specificity
Immune cell enhanced (basophil)
Cell line specificity
Low cell line specificity
Interaction
Component of the HBO1 complex composed of KAT7/HBO1, MEAF6, ING5, and one scaffold subunit: complexes containing BRPF scaffold (BRPF1, BRD1/BRPF2 or BRPF3) direct KAT7/HBO1 specificity towards H3K14ac, while complexes containing JADE scaffold (JADE1, JADE2 and JADE3) mediate acetylation of histone H4 (PubMed:16387653, PubMed:24065767). Component of the MOZ/MORF complex composed at least of ING5, KAT6A, KAT6B, MEAF6 and one of BRPF1, BRD1/BRPF2 and BRPF3 (PubMed:16387653, PubMed:18794358). Interacts with H3K4me3 and to a lesser extent with H3K4me2 (PubMed:16728974, PubMed:18623064). Interacts with EP300 and p53/TP53 (PubMed:12750254). Interacts with INCA1 (PubMed:21750715).
Molecular function
Activator, Chromatin regulator
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