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INTS3

Anti-INTS3 Products

Rabbit Anti-Human INTS3 Antibody (MOB-0351MC)
- Species Reactivity: Human, Cow, Dog, Horse, Pig
- Application: WB, IHC-P, P-ELISA
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Anti-INTS3 Immunohistochemistry Kit (VS-0325-XY1132)
- Species Reactivity: Human, Mouse, Rat
- Target: INTS3
- Application: IHC
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For Research Use Only. Not For Clinical Use.

Background

The protein encoded by this gene can form a complex with human single-strand DNA binding proteins 1 or 2 (hSSB1 and hSSB2) and other proteins to mediate genome stability and the DNA damage response. The encoded protein is also part of a multiprotein complex that interacts with the C-terminal domain of RNA polymerase II large subunit to help regulate processing of U1 and U2 small nuclear RNAs.

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Immune cell enhanced (non-classical monocyte)

Cell line specificity

Low cell line specificity

Interaction

Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12. Component of the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS complexes containing SOSS-B1/NABP2 are more abundant than complexes containing SOSS-B2/NABP1. Interacts with SOSS-B1/NABP2, SOSS-B2/NABP1 and SOSS-C/INIP; the interaction is direct. Interacts with NBN/NBS1.

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