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IZUMO1
Anti-IZUMO1 Recombinant Antibody Products
- Rat Anti-IZUMO1 Recombinant Antibody (MOB-3757z) (MOB-3757z)
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- Species Reactivity: Human, Mouse
- Type: Rat IgG2a
- Application: WB, ICC, IF, IP
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- Recombinant Anti-Human IZUMO1 Antibody scFv Fragment (MOB-3757z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: ELISA, IF, FuncS
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- Recombinant Anti-Human IZUMO1 Antibody Fab Fragment (MOB-3757z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: ELISA, Nert, FuncS
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For Research Use Only. Not For Clinical Use.
Protein class
Transporters
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Early spermatids, Late spermatids)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (hTCEpi)
Interaction
Monomer (PubMed:27309808, PubMed:27309818). Monomer, homodimer and homooligomer; depending on the context (By similarity). Interacts with IZUMO1R/JUNO. IZUMO1 and IZUMO1R/JUNO form a complex with 1:1 stoichiometry (PubMed:27309808, PubMed:27309818). In gamete recognition, IZUMO1R/JUNO first binds to monomeric IZUMO1 (By similarity). The weak, but specific interaction with IZUMO1R/JUNO induces IZUMO1 homodimerization (By similarity). The process follows a tight binding phase where IZUMO1 bends the entire structure towards the sperm membrane side through a thiol-disulfide exchange reaction (By similarity). The molecule no longer binds to IZUMO1R/JUNO and instead binds to a putative second oocyte receptor (By similarity). Interacts with ACE3 (By similarity).
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