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KALRN
Huntington's disease (HD), a neurodegenerative disorder characterized by loss of striatal neurons, is caused by an expansion of a polyglutamine tract in the HD protein huntingtin. This gene encodes a protein that interacts with the huntingtin-associated protein 1, which is a huntingtin binding protein that may function in vesicle trafficking.
Protein class
Cancer-related genes, Enzymes, Human disease related genes, Metabolic proteins
Predicted location
Intracellular, Membrane (different isoforms)
Single cell type specificity
Group enriched (Excitatory neurons, Inhibitory neurons)
Immune cell specificity
Immune cell enhanced (T-reg)
Cell line specificity
Cell line enhanced (CACO-2, HEL, OE19, SH-SY5Y)
Interaction
Interacts with the C-terminal of peptidylglycine alpha-amidating monooxygenase (PAM) and with the huntingtin-associated protein 1 (HAP1) (By similarity). Interacts with FASLG.
Molecular function
Guanine-nucleotide releasing factor, Kinase, Serine/threonine-protein kinase, Transferase
More Types Infomation
- Recombinant Anti-Human KALRN Antibody (MOB-3762z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, IP, FuncS
- Recombinant Anti-Human KALRN Antibody scFv Fragment (MOB-3762z-S(P))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: scFv
- Application: FC, WB, FuncS
- Recombinant Anti-Human KALRN Antibody Fab Fragment (MOB-3762z-F(E))
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Fab
- Application: WB, ELISA, FuncS
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- Scaffold Name: PDZ domain
- Target: Kalirin-7
- Species Reactivity: Human
- Derivation: Yeast Two-hybrid
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For Research Use Only. Not For Clinical Use.