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KANK1
Anti-KANK1 Recombinant Antibody Products
- Mouse Anti-KANK1 Recombinant Antibody (VS3-FY2748) (VS3-FY2748)
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- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, IHC
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- Recombinant Mouse Anti-Human KANK1 Antibody (MOB-0632MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Anti-KANK1 Immunohistochemistry Kit (VS-0325-XY1171)
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- Species Reactivity: Human, Mouse, Rat
- Target: KANK1
- Application: IHC
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For Research Use Only. Not For Clinical Use.
The protein encoded by this gene belongs to the Kank family of proteins, which contain multiple ankyrin repeat domains. This family member functions in cytoskeleton formation by regulating actin polymerization. This gene is a candidate tumor suppressor for renal cell carcinoma. Mutations in this gene cause cerebral palsy spastic quadriplegic type 2, a central nervous system development disorder. A t(5;9) translocation results in fusion of the platelet-derived growth factor receptor beta gene (PDGFRB) on chromosome 5 with this gene in a myeloproliferative neoplasm featuring severe thrombocythemia. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 20.
Protein class
Disease related genes, Human disease related genes, Plasma proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Astrocytes, Oligodendrocyte precursor cells, Late spermatids, Oligodendrocytes)
Immune cell specificity
Immune cell enhanced (plasmacytoid DC)
Cell line specificity
Cell line enhanced (Hep G2)
Interaction
Interacts with YWHAQ; the interaction requires KANK1 phosphorylation at Ser-325 and is enhanced by growth factor stimulation (PubMed:18458160). Interacts with YWHAB, YWHAG, YWHAE, YWHAH, YWHAZ and SFN; the interaction requires KANK1 phosphorylation at Ser-325 (PubMed:18458160). Interacts with ARFGEF1; however, colocalization cannot be experimentally confirmed (PubMed:22084092). Interacts with BAIAP2 (PubMed:19171758). Interacts (via ANK repeats 1-5) with KIF21A (via residues 1146-1167); KIF21A enhances translocation of KANK1 to the plasma membrane (PubMed:19559006, PubMed:29183992). Interacts with CTNNB1 (PubMed:16968744).
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