Anti-KCND2 Products

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For Research Use Only. Not For Clinical Use.

KCND2 (Kv4.2) is a major regulator of firing rates and integration in neurons, so Creative Biolabs takes pride in supplying the highest-quality anti-KCND2 (Kv4.2) recombinant antibodies for neuroscience research. As the pore-forming alpha subunit of the A-type potassium channel, KCND2 is the master regulator of neuronal firing rates and signal integration. Our validated anti-KCND2 antibodies are designed to be an effective research tool for exploring epilepsy, ataxia, and basic neuronal excitability.

KCND2: A Key Regulator of Neuronal Firing

Potassium Voltage-Gated Channel Subfamily D Member 2, also known as Kv4.2, is the pore-forming alpha subunit of the rapidly inactivating, A-type potassium channel. These channels are highly expressed in neuronal dendrites and soma throughout the brain, especially in the hippocampus and cerebellum. Kv4.2 channels are activated upon membrane depolarization to generate a transient outward potassium current, thereby reducing back-propagating action potentials and setting the frequency of neuronal firing. Dysregulation of Kv4.2 expression is implicated in a number of neurological disorders, such as epilepsy and spinocerebellar ataxia.

Alternative Names

KCND2; potassium channel, voltage gated Shal related subfamily D, member 2; RK5; KV4.2; potassium voltage-gated channel subfamily D member 2; voltage-sensitive potassium channel; voltage-gated potassium channel subunit Kv4.2; potassium voltage-gated channel, Shal-related subfamily, member 2;

Background

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member mediates a rapidly inactivating, A-type outward potassium current which is not under the control of the N terminus as it is in Shaker channels.

Anti-KCND2 rAb Products

Creative Biolabs' anti-KCND2 recombinant antibodies are designed to recognize the Kv4.2 channel subunit with high affinity and exquisite specificity. Our KCND2 antibodies are thoroughly validated for use in challenging applications, such as IHC of brain tissue and co-immunoprecipitation to pull-down its interaction with accessory subunits (e.g., KChIPs). Get the power and precision to investigate this important ion channel with our rAbs.

Table 1. Featured anti-KCND2 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs is proud to offer a full spectrum of antibody products for the growing and innovative field of neuroscience research. Our anti-KCND2 recombinant antibodies are produced using advanced expression platforms. They are designed in optimized mammalian systems to ensure they will recognize the native, tetrameric form of the ion channel protein, and deliver an antibody with high biological activity.

Featured Anti-KCND2 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-KCND2 recombinant antibody production.

Fig.2 Gram-scale anti-KCND2 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to providing scientists with the tools they need to power the next breakthrough. For anti-KCND2 research, we offer a wide range of customizable antibody modalities to support your investigation of this important ion channel and the debilitating diseases it can cause when misregulated.

Fig.3 Full-length anti-KCND2 recombinant antibody production and modalities.

Precision has never been more important when investigating neuronal excitability. Creative Biolabs' validated, lot-to-lot consistent anti-KCND2 recombinant antibodies will help you to unlock the secrets of epilepsy, ataxia, and fundamental neurophysiology. Give our products a try and experience the quality for yourself. Contact one of our expert scientists today.