Anti-KCNJ10 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs supports the latest neuroscience and renal physiology research by providing unparalleled anti-KCNJ10 (Kir4.1) recombinant antibodies. KCNJ10 encodes an important inwardly rectifying potassium channel expressed in glia in the brain and involved in ion transport in the kidney. Creative's top quality antibodies against KCNJ10 are indispensable tools to study epilepsy, EAST/SeSAME syndrome, and basic potassium homeostasis mechanisms.

KCNJ10: A Critical Potassium Channel in Glia and the Kidney

Potassium channel subfamily J member 10 (KCNJ10), also known as Kir4.1, is an inwardly rectifying potassium channel. KCNJ10 is highly expressed in astrocytes of the central nervous system, where it forms channels that are essential for buffering extracellular potassium released during neuronal activity. This buffering activity is critical for maintaining neuronal excitability. In the kidney, Kir4.1 is found in the distal convoluted tubule, and is important for potassium and salt reabsorption. Mutations in the KCNJ10 gene that result in loss of function of the Kir4.1 channel cause EAST/SeSAME syndrome (Epilepsy, Ataxia, Sensorineural deafness, and a salt-wasting Tubulopathy), a devastating disease.

Alternative Names

KCNJ10; potassium channel, inwardly rectifying subfamily J, member 10; KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN; ATP-sensitive inward rectifier potassium channel 10; inward rectifier K+ channel KIR1.2; inward rectifier K(+) channel Kir1.2; ATP-dependen

Background

This gene encodes a member of the inward rectifier-type potassium channel family, characterized by having a greater tendency to allow potassium to flow into, rather than out of, a cell. The encoded protein may form a heterodimer with another potassium channel protein and may be responsible for the potassium buffering action of glial cells in the brain. Mutations in this gene have been associated with seizure susceptibility of common idiopathic generalized epilepsy syndromes. [provided by RefSeq, Jul 2008]

Anti-KCNJ10 rAb Products

Creative Biolabs' anti-KCNJ10 recombinant antibodies were engineered to be of the highest affinity and specificity for robust detection of the Kir4.1 ion channel. They are validated for critical applications such as IHC on brain and kidney tissue as well as co-immunoprecipitation to identify interaction with other channel subunits (Kir5.1, for example). Creative's rAbs offer researchers the precision needed to study this important ion channel.

Table 1. Featured anti-KCNJ10 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

To empower today's cutting edge neuroscience and renal research, Creative Biolabs leverages the latest antibody production platforms. Our anti-KCNJ10 recombinant antibodies are expressed in a highly optimized mammalian system to recognize the native, tetrameric form of the ion channel and ensure a biologically active product.

Featured Anti-KCNJ10 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-KCNJ10 recombinant antibody production.

Fig.2 Gram-scale anti-KCNJ10 recombinant antibody production.

rAb Modalities

Creative Biolabs is passionate about propelling scientific discovery forward by offering a diverse suite of flexible antibody solutions. Our anti-KCNJ10 recombinant antibodies are available in a variety of customizable formats to best meet the needs of researchers around the world and help them to study this critical ion channel and the severe disorders associated with its dysfunction.

Fig.3 Full-length anti-KCNJ10 recombinant antibody production and modalities.

Empower your studies of potassium homeostasis with Creative Biolabs' anti-KCNJ10 recombinant antibodies. Our portfolio of rigorously validated and consistent products will meet the needs of your research in epilepsy, rare genetic disease, and renal physiology. Choose Creative Biolabs and our Antibody Quality you can trust to partner with you to take your science to the next level. Contact our expert staff today.