KCNMB3

Recombinant Antibody Products Formats

Anti-KCNMB3 Recombinant Antibody Products

Recombinant Mouse anti-Human KCNMB3 Monoclonal antibody (EML1469) (MOB-0099CT)
- Species Reactivity: Human
- Application: WB
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Hi-Affi™ Recombinant Rabbit Anti-KCNMB3 Monoclonal Antibody (DS1919AB) (MOR-1919)
- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: WB, FC
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For Research Use Only. Not For Clinical Use.

MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. MaxiK channels can be formed by 2 subunits: the pore-forming alpha subunit and the modulatory beta subunit. The protein encoded by this gene is an auxiliary beta subunit which may partially inactivate or slightly decrease the activation time of MaxiK alpha subunit currents. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 22.

Protein class

FDA approved drug targets, Transporters

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enhanced (Cone photoreceptor cells, Late spermatids, Early spermatids)

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (CACO-2, HEL, NB-4)

Interaction

Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB3 per KCNMA1 tetramer.

Molecular function

Ion channel

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