Anti-KCNMB4 Products

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For Research Use Only. Not For Clinical Use.

Creative Biolabs specialises in neuroscience and ion channel research and our anti-KCNMB4 recombinant antibodies are highly specific. KCNMB4 is a brain-specific regulatory beta subunit of the BK channel. It is a crucial fine-tuner of neuronal excitability, so the best antibodies are needed to study the mechanisms underlying the fine-tuning of ion channel function and its role in preventing pathological hyperexcitability in neurological diseases like epilepsy.

KCNMB4: A Brake on Neuronal Excitability

Potassium Large Conductance Calcium-Activated Channel, Subunit Beta 4 (KCNMB4) is an auxiliary subunit of the BK potassium channel that is selectively expressed in the brain. It co-assembles with the pore-forming KCNMA1 subunit and confers a unique set of properties to the channel. Most notably, KCNMB4 appears to increase the apparent calcium sensitivity of the BK channel, and slows the activation kinetics of the channel. The resulting effect of these changes is to act as a strong "brake" on the repetitive firing of the neuron and to protect against hyperexcitability. Loss-of-function mutations in KCNMB4 cause forms of epilepsy.

Alternative Names

Calcium-activated potassium channel subunit beta-4; BK channel beta subunit 4; BK channel subunit beta-4; BKbeta4

Background

KCNMB4 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4) is a Protein Coding gene. It's a regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels that are fundamental to the control of smooth muscle tone and neuronal excitability. Diseases associated with KCNMB4 include Parosteal Osteosarcoma, Peripheral Osteosarcoma.

Anti-KCNMB4 rAb Products

Our anti-KCNMB4 recombinant antibodies are engineered for maximum specificity. We validate our antibodies to ensure that they can detect the beta-4 subunit with high sensitivity and with no cross-reactivity with related KCNMB family members (beta 1, 2 or 3). This is important to study the unique, brain-specific function of this subunit. Optimized for IHC and co-immunoprecipitation, our rAbs give unambiguous, clear results.

Table 1. Featured anti-KCNMB4 recombinant antibody products at Creative Biolabs.

Customer Reviews

rAb Production

Creative Biolabs has a state-of-the-art platform for recombinant antibody production to service the highly specialized field of neuroscience research. Our anti-KCNMB4 recombinant antibodies are raised against a unique extracellular loop of the protein and will detect KCNMB4 on the surface of live neurons.

Featured Anti-KCNMB4 Recombinant Antibody Production Platforms
Fig.1 Milligram-scale anti-KCNMB4 recombinant antibody production.

Fig.2 Gram-scale anti-KCNMB4 recombinant antibody production.

rAb Modalities

Creative Biolabs is committed to empowering your science by making antibody research more flexible. Our anti-KCNMB4 recombinant antibodies are available in a variety of formats that are customizable to fit the unique needs of your experiments. We want to provide the best tools possible to researchers around the globe to study this important channel regulator.

Fig.3 Full-length anti-KCNMB4 recombinant antibody production and modalities.

Probe the fine-tuning of neuronal excitability with the high quality anti-KCNMB4 recombinant antibodies from Creative Biolabs. We provide the validation and specificity you need to study this unique protein with confidence. Trust our expertise to give your research a strong foundation. Call our scientific team today.