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KCNMB4
KCNMB4 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4) is a Protein Coding gene. It's a regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. Diseases associated with KCNMB4 include Parosteal Osteosarcoma and Peripheral Osteosarcoma.
Protein class
FDA approved drug targets
Predicted location
Membrane
Single cell type specificity
Cell type enhanced (Excitatory neurons, Oligodendrocytes, Inhibitory neurons, Hepatic stellate cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (NTERA-2, RH-30, RT4, SuSa)
Interaction
Interacts with KCNMA1 tetramer (PubMed:10692449, PubMed:10804197). There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer (PubMed:10692449, PubMed:10804197). Interacts with FMR1 (via N-terminus) (PubMed:25561520).
Molecular function
Ion channel
More Types Infomation
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- Species Reactivity: Human
- Application: ELISA
- Rabbit Anti-KCNMB4 Recombinant Antibody (clone rL18A/3R) (VS-0422-LC32)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF
- Human Anti-KCNMB4 Recombinant Antibody (clone hL18A/3R) (VS-0422-LC31)
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- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: WB, IF
- Rat Anti-KCNMB4 Recombinant Antibody (clone rtL18A/3R) (VS-0422-LC30)
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- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: WB, IF
- Mouse Anti-KCNMB4 Recombinant Antibody (clone mL18A/3R) (VS-0422-LC29)
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- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: WB, IF
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For Research Use Only. Not For Clinical Use.