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KCNMB4

Anti-KCNMB4 Products

Recombinant Mouse anti-Human KCNMB4 Monoclonal antibody (EML1512) (MOB-0100CT)
- Species Reactivity: Human
- Application: ELISA
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Mouse Anti-KCNMB4 Recombinant Antibody (clone mL18A/3R) (VS-0422-LC29)
- Species Reactivity: Rat, Human, Mouse
- Type: Mouse IgG2a
- Application: WB, IF
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Rat Anti-KCNMB4 Recombinant Antibody (clone rtL18A/3R) (VS-0422-LC30)
- Species Reactivity: Rat, Human, Mouse
- Type: Rat IgG2b
- Application: WB, IF
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Human Anti-KCNMB4 Recombinant Antibody (clone hL18A/3R) (VS-0422-LC31)
- Species Reactivity: Rat, Human, Mouse
- Type: Human IgG1
- Application: WB, IF
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Rabbit Anti-KCNMB4 Recombinant Antibody (clone rL18A/3R) (VS-0422-LC32)
- Species Reactivity: Rat, Human, Mouse
- Type: Rabbit IgG
- Application: WB, IF
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For Research Use Only. Not For Clinical Use.

Background

KCNMB4 (Potassium Calcium-Activated Channel Subfamily M Regulatory Beta Subunit 4) is a Protein Coding gene. It's a regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. MaxiK channels are large conductance, voltage and calcium-sensitive potassium channels which are fundamental to the control of smooth muscle tone and neuronal excitability. Diseases associated with KCNMB4 include Parosteal Osteosarcoma and Peripheral Osteosarcoma.

Protein class

FDA approved drug targets

Predicted location

Membrane

Single cell type specificity

Cell type enhanced (Excitatory neurons, Oligodendrocytes, Inhibitory neurons, Hepatic stellate cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (NTERA-2, RH-30, RT4, SuSa)

Interaction

Interacts with KCNMA1 tetramer (PubMed:10692449, PubMed:10804197). There are probably 4 molecules of KCMNB4 per KCNMA1 tetramer (PubMed:10692449, PubMed:10804197). Interacts with FMR1 (via N-terminus) (PubMed:25561520).

Molecular function

Ion channel

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