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KLC3
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the kinesin light chain gene family. Kinesins are molecular motors involved in the transport of cargo along microtubules, and are composed of two kinesin heavy chain (KHC) and two kinesin light chain (KLC) molecules. KLCs are thought to typically be involved in binding cargo and regulating kinesin activity. In the rat, a protein similar to this gene product is expressed in post-meiotic spermatids, where it associates with structural components of sperm tails and mitochondria.
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Prostatic glandular cells, Basal prostatic cells, Ductal cells)
Immune cell specificity
Not detected in immune cells
Cell line specificity
Cell line enhanced (A-431, HaCaT, HBEC3-KT, hTCEpi)
Interaction
Oligomer composed of two heavy chains and two light chains. Associates with microtubulin in an ATP-dependent manner. Interacts with KIF5C. Interacts with ODF1 (By similarity). Interacts with LRGUK (By similarity). Interacts with VDAC2 (By similarity).
Molecular function
Motor protein
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