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KLHL25

Anti-KLHL25 Products

Recombinant Mouse anti-Human KLHL25 Monoclonal antibody (EML847) (MOB-1033CT)
- Species Reactivity: Human
- Application: WB
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Mouse Anti-KLHL25 Recombinant Antibody (ZG-0251C) (ZG-0251C)
- Species Reactivity: Human
- Type: Mouse IgG
- Application: WB, ELISA
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Mouse Anti-KLHL25 Recombinant Antibody (clone 1B7) (VS3-QX647)
- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG2b
- Application: WB, IHC, ICC, FC, ELISA
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Chicken Anti-KLHL25 Polyclonal IgY (BRD-0778MZ)
- Species Reactivity: Human
- Type: Chicken antibody
- Application: ICC, IF, WB
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For Research Use Only. Not For Clinical Use.

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Horizontal cells)

Immune cell specificity

Immune cell enhanced (non-classical monocyte)

Cell line specificity

Low cell line specificity

Interaction

Component of the BCR(KLHL25) E3 ubiquitin ligase complex, at least composed of CUL3, KLHL25 and RBX1. Interacts with EIF4EBP1 (when hypophosphorylated).

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