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KRT83

The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex.
Protein class

Disease related genes, Human disease related genes

Predicted location

Intracellular

Single cell type specificity

Not detected

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enriched (RPMI-8226)

Interaction

Heterotetramer of two type I and two type II keratins.

More Types Infomation

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For Research Use Only. Not For Clinical Use.

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