LCMT2

The protein encoded by this intronless gene belongs to the highly variable methyltransferase superfamily. This gene is the inferred homolog of the Saccharomyces cerevisiae carboxymethyltransferase gene PPM2 that is essential for the synthesis of the hypermodified guanosine Wybutosine (yW).LCMT2 (Leucine Carboxyl Methyltransferase 2) is a Protein Coding gene. Among its related pathways are tRNA processing and Gene Expression. Gene Ontology (GO) annotations related to this gene include methyltransferase activity. An important paralog of this gene is LCMT1.Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3-position adjacent to the anticodon of eukaryotic phenylalanine tRNA (By similarity). May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues.