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LHCGR

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For Research Use Only. Not For Clinical Use.


This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia.
Protein class

Disease related genes, FDA approved drug targets, G-protein coupled receptors, Human disease related genes

Predicted location

Intracellular, Membrane (different isoforms)

Single cell type specificity

Cell type enriched (Theca cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Not detected

Molecular function

G-protein coupled receptor, Receptor, Transducer

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