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LHX2

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For Research Use Only. Not For Clinical Use.


This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]
Protein class

Transcription factors

Predicted location

Intracellular

Single cell type specificity

Cell type enhanced (Muller glia cells, Astrocytes, Early spermatids)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Cell line enhanced (AN3-CA, GAMG, HAP1, HeLa, NTERA-2, U-138 MG)

Interaction

Interacts (via LIM domains) with CITED2. Interacts with POU4F2.

Molecular function

Activator, DNA-binding

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