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LOXL4

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For Research Use Only. Not For Clinical Use.


Background

This gene encodes a member of the lysyl oxidase gene family. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyses the first step in the formation of crosslinks in collagens and elastin. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family.
Predicted location

Secreted

Single cell type specificity

Cell type enriched (Basal respiratory cells)

Immune cell specificity

Not detected in immune cells

Cell line specificity

Group enriched (BJ hTERT+, CAPAN-2)

Molecular function

Oxidoreductase

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