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LPL
Loading...Anti-LPL Products
- Mouse Anti-LPL Recombinant Antibody (clone 27G9) (MOB-1478z)
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IP
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- Mouse Anti-LPL Recombinant Antibody (clone 2C5) (VS3-XY1018)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: ELISA, WB
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- Species Reactivity: Human, Rat, Syrian Hamster. Does not react with Mouse
- Type: Mouse IgG1
- Application: ELISA, WB, IP
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- Species Reactivity: Human, Rat, Syrian Hamster. Does not react with Mouse
- Type: Mouse IgG1
- Application: IF (post Permeabilisation), ELISA, WB, FC, Inhib
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- Mouse Anti-LPL Recombinant Antibody (clone 5D2) (VS1-YJ129)
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- Species Reactivity: Human, Mouse, Rat, Syrian Hamster, Cat
- Type: Mouse IgG1
- Application: IF (post Permeabilisation), ELISA, WB, FC, Inhib
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- Recombinant Mouse Anti-LPL Antibody (CBL234) (NEUT-1699CQ)
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- Species Reactivity: Bovine
- Type: IgG1
- Application: ELISA, Neut
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- Anti-Mouse LPL Immunohistochemistry Kit (VS-0525-XY4081)
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- Species Reactivity: Human, Mouse, Rat
- Target: LPL
- Application: IHC
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- Anti-LPL Immunohistochemistry Kit (VS-0325-XY1263)
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- Species Reactivity: Human, Mouse, Rat
- Target: LPL
- Application: IHC
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For Research Use Only. Not For Clinical Use.
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism.
Protein class
Candidate cardiovascular disease genes, Disease related genes, Enzymes, FDA approved drug targets, Human disease related genes, Metabolic proteins, Plasma proteins
Predicted location
Intracellular, Secreted (different isoforms)
Single cell type specificity
Cell type enhanced (Granulosa cells, Cardiomyocytes, Adipocytes, Sertoli cells, Horizontal cells)
Immune cell specificity
Immune cell enhanced (non-classical monocyte)
Cell line specificity
Cell line enriched (AF22)
Interaction
Homodimer (PubMed:16179346, PubMed:26725083, PubMed:11893776) (Probable). Interacts with GPIHBP1 with 1:1 stoichiometry (PubMed:17997385, PubMed:27929370, PubMed:26725083, PubMed:27811232, PubMed:29899144, PubMed:30559189). Interacts with APOC2; the interaction activates LPL activity in the presence of lipids (By similarity). Interaction with heparan sulfate proteoglycans is required to protect LPL against loss of activity (PubMed:11342582). Associates with lipoprotein particles in blood plasma (PubMed:11342582, PubMed:11893776). Interacts with LMF1 and SEL1L; interaction with SEL1L is required to prevent aggregation of newly synthesized LPL in the endoplasmic reticulum (ER), and for normal export of LPL from the ER to the extracellular space (PubMed:25066055). Interacts with SORL1; SORL1 acts as a sorting receptor, promoting LPL localization to endosomes and later to lysosomes, leading to degradation of newly synthesized LPL (PubMed:21385844).
Molecular function
Heparin-binding, Hydrolase
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