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LY96
Anti-LY96 Recombinant Antibody Products
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- Derivation: Mouse
- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, ELISA, IF, IHC
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- Recombinant Mouse Anti-LY96 Antibody (NEUT-1712CQ) (NEUT-1712CQ)
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- Species Reactivity: Human
- Type: IgG2b
- Application: Neut, FC
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For Research Use Only. Not For Clinical Use.
This gene encodes a protein which associates with toll-like receptor 4 on the cell surface and confers responsiveness to lipopolysaccyaride (LPS), thus providing a link between the receptor and LPS signaling. Studies of the mouse ortholog suggest that this gene may be involved in endotoxin neutralization. Alternative splicing results in multiple transcript variants encoding different isoforms.
Predicted location
Secreted
Single cell type specificity
Cell type enhanced (Hofbauer cells, Kupffer cells, Macrophages, Plasma cells, Langerhans cells, monocytes)
Immune cell specificity
Immune cell enriched (neutrophil)
Cell line specificity
Cell line enhanced (GAMG, Karpas-707, RPMI-8226, U-87 MG)
Interaction
Heterogeneous homomer formed from homodimers; disulfide-linked (PubMed:11593030, 12642668). Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, LY96 and TLR4 (PubMed:11274165). Binds to the extracellular domains of TLR2 and TLR4 (PubMed:10359581, 11593030, 17803912). Ligand binding induces interaction with TLR4 and oligomerization of the complex.
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