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MAP2K5
Loading...Anti-MAP2K5 Products
- Mouse Anti-MAP2K5 Recombinant Antibody (clone 2G10) (VS3-XY1027)
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- Species Reactivity: Human
- Application: WB
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- Recombinant Mouse Anti-Human MAP2K5 Antibody (MOB-1460MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Derivation: Phage display library screening
- Species Reactivity: Human
- Type: IgG
- Application: ICC, IF, WB
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- Mouse Anti-MAP2K5 Recombinant Antibody (clone 5H11B10) (VS7-0425-WR339)
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- Species Reactivity: Human
- Type: Mouse IgG1
- Application: WB, IHC, FC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK7/ERK5. This kinase itself can be phosphorylated and activated by MAP3K3/MEKK3, as well as by atypical protein kinase C isoforms (aPKCs). The signal cascade mediated by this kinase is involved in growth factor stimulated cell proliferation and muscle cell differentiation. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been described. [provided by RefSeq, May 2011]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Group enriched (Late spermatids, Excitatory neurons, Inhibitory neurons, Oligodendrocytes, Oligodendrocyte precursor cells, Early spermatids, Astrocytes, Microglial cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with PARD6A, MAP3K3 and MAPK7. Forms a complex with SQSTM1 and PRKCZ or PRKCI (By similarity). (Microbial infection) Interacts with Yersinia YopJ.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase
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