MAP4K5
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a member of the serine/threonine protein kinase family, that is highly similar to yeast SPS1/STE20 kinase. Yeast SPS1/STE20 functions near the beginning of the MAP kinase signal cascades that is essential for yeast pheromone response. This kinase was shown to activate Jun kinase in mammalian cells, which suggested a role in stress response. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
Protein class
Enzymes, Metabolic proteins
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Group enriched (basophil, eosinophil)
Cell line specificity
Low cell line specificity
Interaction
Interacts with both SH3 domains of the adapter proteins CRK and CRKL.
Molecular function
Kinase, Serine/threonine-protein kinase, Transferase
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