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MAX

Anti-MAX Products

AbPlus™ Anti-MAX Magnetic Beads (VS-0724-YC1042) (VS-0724-YC1042)
- Target: MAX
- Target Species: Human
- Application: IP, Protein Purification
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Recombinant Mouse anti-Human MAX Monoclonal antibody (84D6b) (MOB-1220CT)
- Species Reactivity: Human
- Application: ChIP, Dot, WB
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Anti-MAX Immunohistochemistry Kit (VS-0325-XY1312)
- Species Reactivity: Human, Mouse, Rat
- Target: MAX
- Application: IHC
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Hi-Affi™ Recombinant Rabbit Anti-MAX Monoclonal Antibody (SI412DS) (MOR-4323)
- Species Reactivity: Human
- Type: IgG
- Application: ELISA, ICC, IF, IF, FC, IP
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For Research Use Only. Not For Clinical Use.

Background

The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Protein class

Cancer-related genes, Disease related genes, Human disease related genes, Transcription factors

Predicted location

Intracellular

Single cell type specificity

Low cell type specificity

Immune cell specificity

Low immune cell specificity

Cell line specificity

Cell line enhanced (HMC-1)

Interaction

Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MYC or MAD. Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, L3MBTL2 and YAF2. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with SPAG9. The heterodimer MYC:MAX interacts with ABI1; the interaction may enhance MYC:MAX transcriptional activity.

Molecular function

Activator, DNA-binding, Repressor

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