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MCPH1
Loading...Anti-MCPH1 Products
- Recombinant Mouse Anti-Human MCPH1 Antibody (MOB-1489MZ)
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- Species Reactivity: Human
- Type: Mouse antibody
- Application: WB
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- Anti-MCPH1 Immunohistochemistry Kit (VS-0525-XY4315)
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- Species Reactivity: Human
- Target: MCPH1
- Application: IHC
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More Infomation
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For Research Use Only. Not For Clinical Use.
Background
This gene encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in this gene have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.
Protein class
Disease related genes, Human disease related genes
Predicted location
Intracellular
Single cell type specificity
Cell type enhanced (Excitatory neurons, Inhibitory neurons, Oligodendrocytes, Oligodendrocyte precursor cells)
Immune cell specificity
Low immune cell specificity
Cell line specificity
Low cell line specificity
Interaction
Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.
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